BD-PB4029-PPM1F Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

PPM1F Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB4029

产品名称

PPM1F Rabbit Polyclonal Antibody (N-term)

别名

Protein phosphatase 1F, Ca(2+)/calmodulin-dependent protein kinase phosphatase, CaM-kinase phosphatase, CaMKPase, Partner of PIX 2, Protein fem-2 homolog, hFem-2, PPM1F, KIAA0015, POPX2

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_055449.1

Human Swissprot No.

P49593

特异性

This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human PPM1F.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

50kDa

同种型

Rabbit IgG

背景介绍

PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.

期货

现货

Western blot analysis of anti-PPM1F Pab in mouse liver tissue lysate (35ug/lane). PPM1F(arrow) was detected using the purified Pab.

Western blot analysis of PPM1F (arrow) using PPM1F Antibody (N-term) either nontransfected (Lane 1) or transiently transfected with the PPM1F gene (Lane 2) .

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.