BD-PB4020-IMPDH2 Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

IMPDH2 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB4020

产品名称

IMPDH2 Rabbit Polyclonal Antibody (N-term)

别名

Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-II, IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD2

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Gene ID

NP_000875.2

Human Swissprot No.

P12268

特异性

This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-137 amino acids from the N-terminal region of human IMPDH2.

稀释度

WB~~1:1000;IHC-P~~1:100~500;FC~~1:10~50

预测分子量

56kDa

同种型

Rabbit IgG

背景介绍

IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

组织表达

IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor

细胞定位

Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion.

期货

现货

Western blot analysis of IMPDH2 Antibody (N-term) in NCI-H460 cell line and mouse lung tissue lysates (35ug/lane). IMPDH2 (arrow) was detected using the purified Pab.

IMPDH2 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IMPDH2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

IMPDH2 Antibody (N-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.