BD-PB4008

HMGCR Rabbit Polyclonal Antibody (Center)

3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR

常规抗体

WB

Human, Rat, Mouse

NP_000850.1;NP_001124468.1

P04035

This HMGCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380~410 amino acids from the Center region of human HMGCR.

WB~~1:1000;IHC-P~~1:100~500

97kDa

Rabbit IgG

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

[Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix.

Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}. Peroxisome membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00347}

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