产品名称
TRIM22 Rabbit Polyclonal Antibody(N-term)
别名
E3 ubiquitin-protein ligase TRIM22, 632-, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22, TRIM22, RNF94, STAF50
Human Gene ID
NP_001186502.1;NP_006065.2
Human Swissprot No.
Q8IYM9
特异性
This TRIM22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human TRIM22.
背景介绍
The protein encoded by this gene is a member of the
tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
and a coiled-coil region. This protein localizes to the cytoplasm
and its expression is induced by interferon. The protein
down-regulates transcription from the HIV-1 LTR promoter region,
suggesting that function of this protein may be to mediate
interferon's antiviral effects.
组织表达
Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues
细胞定位
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies
