产品名称
PURB Rabbit Polyclonal Antibody
蛋白名称
Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96QR8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96QR8/entry
Mouse Swissprot No.
O35295
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35295
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q68A21
免疫原
Synthesized peptide derived from part region of human protein
特异性
PURB Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008],
组织表达
Expressed in myocardium of heart failure patients.
功能
disease:Defects in PURB may be a cause of progression of myelodysplastic syndrome (MDS) towards acute myelogenous leukemia (AML). MDS refers to a heterogeneous group of closely related hematopoietic disorders. All are characterized by a cellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. Some patients with MDS develop acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development.,function:Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PUR DNA-binding protein family.,subunit:Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.,tissue specificity:Expressed in myocardium of heart failure patients.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.