BD-PB3969-MR1 Rabbit Polyclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

MR1 Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号

BD-PB3969

产品名称

MR1 Rabbit Polyclonal Antibody (C-term)

别名

Major histocompatibility complex class I-related gene protein, MHC class I-related gene protein, Class I histocompatibility antigen-like protein, MR1

类别

常规抗体

推荐应用

反应种属

Human

Human Gene ID

NP_001181928.1;NP_001181929.1;NP_001181964.1;NP_001522.1

Human Swissprot No.

Q95460

特异性

This MR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-341 amino acids from the C-terminal region of human MR1.

稀释度

WB~~1:1000

预测分子量

39kDa

同种型

Rabbit IgG

背景介绍

MR1 has antigen presentation function. Involved in the development and expansion of a small population of T cells expressing an invariant T cell receptor alpha chain called mucosal-associated invariant T cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therfore may be involed in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.

组织表达

Ubiquitous (PubMed:7624800, PubMed:9780177). Low expression is detected in peripheral blood B cells, T cells, monocytes and in bronchial epithelial cells (at protein level) (PubMed:27043408) Expressed in plasmablasts or plasma B cells in the lamina propria of ileum, appendix and colon (at protein level) (PubMed:19760593). Highly expressed on a subset of CD45-positive CD3-positive thymocytes (at protein level) (PubMed:22692454).

细胞定位

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum. [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.

期货

现货

All lanes : Anti-MR1 Antibody (C-term) at 1:1000 dilution Lane 1: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/15000 dilution. Observed band size : 42kDa Blocking/Dilution buffer: 5% NFDM/TBST.

All lanes : Anti-MR1 Antibody (C-term) at 1:1000 dilution Lane 1: MDA-MB-453 whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/15000 dilution. Observed band size : 48kDa Blocking/Dilution buffer: 5% NFDM/TBST.

All lanes : Anti-MR1 Antibody (C-term) at 1:1000 dilution Lane 1: MDA-MB-453 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/15000 dilution. Observed band size : 48kDa Blocking/Dilution buffer: 5% NFDM/TBST.

All lanes : Anti-MR1 Antibody (C-term) at 1:500 dilution Lane 1: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/15000 dilution. Observed band size : 42kDa Blocking/Dilution buffer: 5% NFDM/TBST.

MR1 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the MR1 antibody detected the MR1 protein (arrow).