产品名称
CLC Rabbit Polyclonal Antibody (C-term)
别名
Galectin-10, Gal-10, Charcot-Leyden crystal protein, CLC, Eosinophil lysophospholipase, Lysolecithin acylhydrolase, CLC, LGALS10, LGALS10A
Human Gene ID
NP_001819.2
Human Swissprot No.
Q05315
特异性
This CLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the C-terminal region of human CLC.
背景介绍
Lysophospholipases are enzymes that act on biological
membranes to regulate the multifunctional lysophospholipids. The
protein encoded by this gene is a lysophospholipase expressed in
eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to
glycerophosphocholine and a free fatty acid. This protein may
possess carbohydrate or IgE-binding activities. It is both
structurally and functionally related to the galectin family of
beta-galactoside binding proteins. It may be associated with
inflammation and some myeloid leukemias.
组织表达
Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level)
细胞定位
Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell
