产品名称
PURA Rabbit Polyclonal Antibody
蛋白名称
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q00577
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q00577/entry
Mouse Swissprot No.
P42669
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P42669
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P86252
免疫原
Synthesized peptide derived from part region of human protein
特异性
PURA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008],
组织表达
Brain,Epithelium,Fetal liver,PCR rescued clones,
功能
function:This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.,similarity:Belongs to the PUR DNA-binding protein family.,subunit:Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
