产品名称
RING1 Rabbit Polyclonal Antibody (N-term)
别名
E3 ubiquitin-protein ligase RING1, 632-, Polycomb complex protein RING1, RING finger protein 1, Really interesting new gene 1 protein, RING1, RNF1
Human Gene ID
NP_002922.2
Human Swissprot No.
Q06587
特异性
This RING1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human RING1.
背景介绍
This gene belongs to the RING finger family, members of
which encode proteins characterized by a RING domain, a
zinc-binding motif related to the zinc finger domain. The gene
product can bind DNA and can act as a transcriptional repressor. It
is associated with the multimeric polycomb group protein complex.
The gene product interacts with the polycomb group proteins BMI1,
EDR1, and CBX4, and colocalizes with these proteins in large
nuclear domains. It interacts with the CBX4 protein via its
glycine-rich C-terminal domain. The gene maps to the HLA class II
region, where it is contiguous with the RING finger genes FABGL and
HKE4.
细胞定位
Nucleus. Nucleus speckle
