BD-PB3953-IDE Rabbit Polyclonal Antibody (Center)-现货抗体产品库武汉枢密脑科学技术有限公司

IDE Rabbit Polyclonal Antibody (Center)

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产品基本信息

产品货号

BD-PB3953

产品名称

IDE Rabbit Polyclonal Antibody (Center)

别名

Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin, IDE

类别

常规抗体

推荐应用

反应种属

Human, Rat, Mouse

Human Gene ID

NP_001159418.1;NP_004960.2

Human Swissprot No.

P14735

特异性

This IDE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-435 amino acids from the Central region of human IDE.

稀释度

WB~~1:1000;IHC-P~~1:100~500

预测分子量

118kDa

同种型

Rabbit IgG

背景介绍

IDE belongs to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response.

组织表达

Detected in brain and in cerebrospinal fluid (at protein level).

细胞定位

Cytoplasm, cytosol. Cell membrane {ECO:0000250|UniProtKB:P35559}. Secreted Note=Present at the cell surface of neuron cells. The membrane- associated isoform is approximately 5 kDa larger than the known cytosolic isoform

期货

现货

Western blot analysis of lysate from K562 cell line, using IDE Antibody (Center)at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.

Western blot analysis of anti-IDE Antibody (Center) in A375 cell line lysates (35ug/lane). IDE (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IDE antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Western blot analysis of lysate from K562 cell line, using IDE Antibody (Center)at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.