产品名称
TTF2 Rabbit Polyclonal Antibody
蛋白名称
Transcription termination factor 2 (EC 3.6.4.-) (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UNY4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UNY4/entry
Mouse Swissprot No.
Q5NC05
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5NC05
免疫原
Synthesized peptide derived from part region of human protein
特异性
TTF2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008],
组织表达
Aorta endothelial cell,Brain,Epithelium,
细胞定位
Cytoplasm . Nucleus . Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
功能
function:DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.,subunit:Interacts with CDC5L. Part of the spliceosome.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
