产品名称
ACSL4 Rabbit Polyclonal Antibody (N-term)
别名
Long-chain-fatty-acid--CoA ligase 4, Long-chain acyl-CoA synthetase 4, LACS 4, ACSL4, ACS4, FACL4, LACS4
Human Gene ID
NP_004449.1;NP_075266.1
Human Swissprot No.
O60488
特异性
This ACSL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human ACSL4.
背景介绍
The protein encoded by this gene is an isozyme of the
long-chain fatty-acid-coenzyme A ligase family. Although differing
in substrate specificity, subcellular localization, and tissue
distribution, all isozymes of this family convert free long-chain
fatty acids into fatty acyl-CoA esters, and thereby play a key role
in lipid biosynthesis and fatty acid degradation. This isozyme
preferentially utilizes arachidonate as substrate. The absence of
this enzyme may contribute to the mental retardation or Alport
syndrome. Alternative splicing of this gene generates 2 transcript
variants.
细胞定位
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane
