产品名称
MCOLN1 Rabbit Polyclonal Antibody (C-term)
别名
Mucolipin-1, MG-2, Mucolipidin, MCOLN1, ML4
Human Gene ID
NP_065394.1
Human Swissprot No.
Q9GZU1
特异性
This MCOLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the C-terminal region of human MCOLN1.
背景介绍
This gene encodes a memberof the transient receptor
potential (TRP) cation channel gene family. The transmembrane
protein localizes to intracellular vesicular membranes including
lysosomes, and functions in the late endocytic pathway and in the
regulation of lysosomal exocytosis. The channel is permeable to
Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes
in Ca(2+) concentration. Mutations in this gene result in
mucolipidosis type IV.
组织表达
Widely expressed in adult and fetal tissues.
细胞定位
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q99J21}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q99J21}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Delivery from the trans-Golgi to lysosomes seems to occur mainly in a direct intracellular manner without intermediate delivery to the plasma membrane (PubMed:16497227) Under normal conditions, restricted to intracellular compartments so that only a very minor proportion is present at the cell membrane (PubMed:12459486, PubMed:18794901, PubMed:28112729, PubMed:29019983)
