BD-PN1435

TAF4B Rabbit Polyclonal Antibody

常规抗体

TAF4B TAF2C2 TAFII105

Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105)

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

6875

Q92750

https://www.uniprot.org/uniprotkb/Q92750/entry

Synthesized peptide derived from part region of human protein

TAF4B Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

94kD

-20°C/1 year

Polyclonal, Rabbit,IgG

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],

Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.

Nucleus . Cytoplasm . Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. .

Basal transcription factors;Huntington's disease;

function:Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B cell-specific transcription.,PTM:Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).,similarity:Belongs to the TAF4 family.,similarity:Contains 1 histone-fold domain.,similarity:Contains 1 TAFH (NHR1) domain.,subcellular location:Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.,subunit:TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription.,tissue specificity:Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.