BD-PB3922

PITRM1 Rabbit Polyclonal Antibody (Center)

Presequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1

常规抗体

WB

Human

NP_001229236.1;NP_001229238.1;NP_055704.2

Q5JRX3

This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.

WB~~1:1000

117kDa

Rabbit IgG

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.

Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta

Mitochondrion matrix

现货