BD-PB3892

EPHA5 (4K13) Mouse Monoclonal Antibody

Ephrin type-A receptor 5, Brain-specific kinase, EPH homology kinase 1, EHK-1, EPH-like kinase 7, EK7, hEK7, EPHA5, BSK, EHK1, HEK7, TYRO4

常规抗体

WB

Human

NP_004430.4;NP_872272.2

P54756

Purified His-tagged EPHA5 protein(Fragment) was used to produced this monoclonal antibody.

WB~~1:2000;IHC-P~~1:100~500

115kDa

IgG1κ

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Two transcript variants encoding different isoforms have been found for this gene.

Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord

Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite

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