产品名称
OVOL2 Rabbit Polyclonal Antibody
蛋白名称
Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BRP0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BRP0/entry
Mouse Swissprot No.
Q8CIV7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CIV7
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
OVOL2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016],
组织表达
Expressed in testis, ovary, heart and skeletal muscle (PubMed:12213202). Expressed in the cornea, but absent from the corneal endothelium (PubMed:26749309).
功能
function:DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription regulator.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 4 C2H2-type zinc fingers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
