BD-PB3888-PINK1 (17J6) Mouse Monoclonal Antibody (Ascites)-现货抗体产品库武汉枢密脑科学技术有限公司

PINK1 (17J6) Mouse Monoclonal Antibody (Ascites)

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产品基本信息

产品货号

BD-PB3888

产品名称

PINK1 (17J6) Mouse Monoclonal Antibody (Ascites)

别名

Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Gene ID

NP_115785.1

Human Swissprot No.

Q9BXM7

特异性

Recombinant PINK1 protein was used to produced this monoclonal antibody.

稀释度

WB~~1:500~2000;IHC-P~~1:100~500

预测分子量

63kDa

同种型

IgG1

背景介绍

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

组织表达

Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development

细胞定位

Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99MQ3}; Single-pass membrane protein. Cytoplasm, cytosol. Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105). When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282)

期货

现货

Western blot analysis of anti-PINK1 Monoclonal Antibody in mouse brain tissue lysates. PINK1(arrow) was detected using the ascites Mab. (dilution 1:500)

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PINK1 Monoclonal Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Formalin-fixed and paraffin-embedded human Brain Cortex tissue reacted with PINK1 Monoclonal Antibody , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Western blot analysis of PINK (arrow) using mouse monoclonal PINK antibody(Ascites). 293 cell lysates (2 μg/lane) either nontransfected (Lane 1) or transiently transfected with the PINK gene (Lane 2) (1:2000)