产品名称
MVP (16V9) Mouse Monoclonal Antibody (N-term) (Ascites)
别名
Major vault protein, MVP, Lung resistance-related protein, MVP, LRP
Human Gene ID
NP_005106.2;NP_059447.2
Human Swissprot No.
Q14764
特异性
This MVP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human MVP.
背景介绍
This gene encodes the major vault protein which is a lung
resistance-related protein. Vaults are multi-subunit structures
that may be involved in nucleo-cytoplasmic transport. This protein
mediates drug resistance, perhaps via a transport process. It is
widely distributed in normal tissues, and overexpressed in
multidrug-resistant cancer cells. The protein overexpression is a
potentially useful marker of clinical drug resistance. This gene
produces two transcripts by using two alternative exon 2 sequences;
however, the open reading frames are the same in both transcripts.
组织表达
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug- resistant cancer cells
细胞定位
Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665)
