产品名称
ITGB2 (3E8) Mouse Monoclonal Antibody
别名
Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7
Human Gene ID
NP_000202.2;NP_001120963.1
Human Swissprot No.
P05107
特异性
Purified His-tagged ITGB2 protein(Fragment) was used to produced this monoclonal antibody.
背景介绍
The product of this gene belongs to the integrin beta
chain family of proteins. Integrins are integral cell-surface
proteins composed of an alpha chain and a beta chain. This gene
encodes the integrin beta chain beta 2. A given chain may combine
with multiple partners resulting in different integrins. For
example, beta 2 combines with the alpha L chain to form the
integrin LFA-1, and combines with the alpha M chain to form the
integrin Mac-1. Integrins are known to participate in cell adhesion
as well as cell-surface mediated signalling. Defects in this gene
are the cause of leukocyte adhesion deficiency type I (LAD1). Two
transcript variants encoding the same protein have been identified
for this gene.
组织表达
Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980)
细胞定位
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein
