产品名称
DISC1 (2B12) Mouse Monoclonal Antibody
别名
Disrupted in schizophrenia 1 protein, DISC1, KIAA0457
Human Gene ID
NP_001012975.1;NP_001012976.1;NP_001012977.1;NP_001158011.1;NP_001158013.1;NP_001158016.1;NP_001158017.1;NP_001158018.1;NP_001158019.1;NP_001158027.1;NP_001158028.1;NP_061132.2
Human Swissprot No.
Q9NRI5
特异性
This DISC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from human DISC1.
背景介绍
This gene encodes a protein with multiple coiled coil
motifs which is located in the nucleus, cytoplasm and mitochondria.
The protein is involved in neurite outgrowth and cortical
development through its interaction with other proteins. This gene
is disrupted in a t(1;11)(q42.1;q14.3) translocation which
segregates with schizophrenia and related psychiatric disorders in
a large Scottish family. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. [provided by
RefSeq].
组织表达
Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q811T9}. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198, PubMed:15797709). Colocalizes with PCNT at the centrosome (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:12506198, ECO:0000269|PubMed:15797709, ECO:0000269|PubMed:18955030}
