产品名称
CD55 (6U13) Mouse Monoclonal Antibody
别名
Complement decay-accelerating factor, CD55, CD55, CR, DAF
Human Gene ID
NP_000565.1;NP_001108224.1
Human Swissprot No.
P08174
特异性
This CD55 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from human CD55.
背景介绍
This gene encodes a protein involved in the regulation of
the complement cascade. The encoded glycoprotein is also known as
the decay-accelerating factor (DAF); binding of DAF to complement
proteins accelerates their decay, disrupting the cascade and
preventing damage to host cells. Antigens present on the DAF
glycoprotein constitute the Cromer blood group system (CROM). Two
alternatively spliced transcripts encoding different proteins have
been identified. The predominant transcript encodes a
membrane-bound protein expressed on cells exposed to plasma
component proteins but an alternatively spliced transcript produces
a soluble protein present at much lower levels. Additional,
alternatively spliced transcript variants have been described, but
their biological validity has not been determined. [provided by
RefSeq].
组织表达
Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted [Isoform 5]: Secreted [Isoform 7]: Cell membrane; Lipid-anchor, GPI-anchor
