产品名称
CDKN1C (18C8) Mouse Monoclonal Antibody (Ascites)
别名
Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2
Human Gene ID
NP_000067.1;NP_001116102.1;NP_001116103.1
Human Swissprot No.
P49918
特异性
This CDKN1C antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from human CDKN1C.
背景介绍
This gene is imprinted, with preferential expression of
the maternal allele. The encoded protein is a tight-binding, strong
inhibitor of several G1 cyclin/Cdk complexes and a negative
regulator of cell proliferation. Mutations in this gene are
implicated in sporadic cancers and Beckwith-Wiedemann syndorome,
suggesting that this gene is a tumor suppressor candidate. Three
transcript variants encoding two different isoforms have been found
for this gene.
组织表达
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver
