产品名称
DDR2 (13L17) Mouse Monoclonal Antibody
别名
Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, DDR2, NTRKR3, TKT, TYRO10
Human Gene ID
NP_001014796.1;NP_006173.2
Human Swissprot No.
Q16832
特异性
This DDR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from human DDR2.
稀释度
WB~~1:100~1600;IHC~~1:200
背景介绍
Receptor tyrosine kinases (RTKs) play a key role in the
communication of cells with their microenvironment. These molecules
are involved in the regulation of cell growth, differentiation, and
metabolism. In several cases the biochemical mechanism by which
RTKs transduce signals across the membrane has been shown to be
ligand induced receptor oligomerization and subsequent
intracellular phosphorylation. This autophosphorylation leads to
phosphorylation of cytosolic targets as well as association with
other molecules, which are involved in pleiotropic effects of
signal transduction. RTKs have a tripartite structure with
extracellular, transmembrane, and cytoplasmic regions. This gene
encodes a member of a novel subclass of RTKs and contains a
distinct extracellular region encompassing a factor VIII-like
domain. Alternative splicing in the 5' UTR results in multiple
transcript variants encoding the same protein. [provided by
RefSeq].
组织表达
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney
细胞定位
Cell membrane; Single-pass type I membrane protein
