产品名称
ITGAX/CD11c (12Y17) Mouse Monoclonal Antibody (N-term)
别名
Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150, CD11c, ITGAX, CD11C
Human Gene ID
NP_000878.2
Human Swissprot No.
P20702
特异性
This ITGAX/CD11c antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 246-274 amino acids from the N-terminal region of human ITGAX/CD11c.
背景介绍
This gene encodes the integrin alpha X chain protein.
Integrins are heterodimeric integral membrane proteins composed of
an alpha chain and a beta chain. This protein combines with the
beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred
to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2
complex seems to overlap the properties of the alpha M beta 2
integrin in the adherence of neutrophils and monocytes to
stimulated endothelium cells, and in the phagocytosis of complement
coated particles.
组织表达
Predominantly expressed in monocytes and granulocytes
细胞定位
Membrane; Single-pass type I membrane protein.
