产品名称
TCF20 Rabbit Polyclonal Antibody
蛋白名称
Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UGU0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UGU0/entry
Mouse Swissprot No.
Q9EPQ8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9EPQ8
免疫原
Synthesized peptide derived from part region of human protein
特异性
TCF20 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
组织表达
Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
功能
domain:The atypical PHD domain functions as a negative modulator of cofactor binding.,function:Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 A.T hook DNA-binding domain.,similarity:Contains 1 PHD-type zinc finger.,subunit:Homodimer (Probable). Interacts with RNF4 and JUN.,tissue specificity:Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
