产品名称
PDGFR (17O9) Mouse Monoclonal Antibody (Ascites)
别名
Platelet-derived growth factor receptor beta, PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, PDGFR-1, CD140b, PDGFRB, PDGFR, PDGFR1
Human Gene ID
NP_002600.1
Human Swissprot No.
P09619
特异性
Purified His-tagged PDGFR protein(Fragment) was used to produced this monoclonal antibody.
背景介绍
This gene encodes a cell surface tyrosine kinase receptor
for members of the platelet-derived growth factor family. These
growth factors are mitogens for cells of mesenchymal origin. The
identity of the growth factor bound to a receptor monomer
determines whether the functional receptor is a homodimer or a
heterodimer, composed of both platelet-derived growth factor
receptor alpha and beta polypeptides. This gene is flanked on
chromosome 5 by the genes for granulocyte-macrophage
colony-stimulating factor and macrophage-colony stimulating factor
receptor; all three genes may be implicated in the 5-q syndrome. A
translocation between chromosomes 5 and 12, that fuses this gene to
that of the translocation, ETV6, leukemia gene, results in chronic
myeloproliferative disorder with eosinophilia. [provided by
RefSeq].
细胞定位
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation
