产品名称
CD79A (16J15) Mouse Monoclonal Antibody (C-term)
别名
B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD79a, CD79A, IGA, MB1
Human Gene ID
NP_001774.1;NP_067612.1
Human Swissprot No.
P11912
特异性
This CD79A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human CD79A.
背景介绍
The B lymphocyte antigen receptor is a multimeric complex
that includes the antigen-specific component, surface
immunoglobulin (Ig). Surface Ig non-covalently associates with two
other proteins, Ig-alpha and Ig-beta, which are necessary for
expression and function of the B-cell antigen receptor. This gene
encodes the Ig-alpha protein of the B-cell antigen component.
Alternatively spliced transcript variants encoding different
isoforms have been described.
细胞定位
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.