产品名称
MAP3K11 (5N9) Mouse Monoclonal Antibody (ascites)
别名
Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11 (
HGNC:6850)
Human Gene ID
NP_002410.1
Human Swissprot No.
Q16584
特异性
This MAP3K11 monoclonal antibody is generated from mouse immunized with MAP3K11 recombinant protein.
背景介绍
The protein encoded by this gene is a member of the
serine/threonine kinase family. This kinase contains a SH3 domain
and a leucine zipper-basic motif. This kinase preferentially
activates MAPK8/JNK kinase, and functions as a positive regulator
of JNK signaling pathway. This kinase can directly phosphorylate,
and activates IkappaB kinase alpha and beta, and is found to be
involved in the transcription activity of NF-kappaB mediated by Rho
family GTPases and CDC42.
组织表达
Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent
