产品名称
ELAVL1 (5E11) Mouse Monoclonal Antibody (Ascites)
别名
ELAV-like protein 1, Hu-antigen R, HuR, ELAVL1, HUR
Human Gene ID
NP_001410.2
Human Swissprot No.
Q15717
特异性
This ELAVL1 monoclonal antibody is generated from mouse immunized with ELAVL1 recombinant protein.
背景介绍
The protein encoded by this gene is a member of the ELAVL
protein family. This encoded protein contains 3 RNA-binding domains
and binds cis-acting AU-rich elements. It destabilizes mRNAs and
thereby regulates gene expression.
组织表达
Ubiquitous. Detected in brain, liver, thymus and muscle.
细胞定位
Cytoplasm. Nucleus. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P70372}. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288) Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462).Localizes to the stress granules in the presence of PLEKHN1 (By similarity) {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:18285462}
