BD-PB3807

PRKAA2 (10F8) Mouse Monoclonal Antibody

5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, PRKAA2, AMPK, AMPK2

常规抗体

WB

Human

NP_006243.2

P54646

This PRKAA2 monoclonal antibody is generated from mouse immunized with PRKAA2 recombinant protein.

WB~~1:1000;IF~~1:10~50

62kDa

IgG2a,K

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Cytoplasm {ECO:0000250|UniProtKB:Q8BRK8}. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters

现货