BD-PB3797

Nephrin (19A1) Mouse Monoclonal Antibody (C-term)

Nephrin, Renal glomerulus-specific cell adhesion receptor, NPHS1, NPHN

常规抗体

WB

Human

NP_004637.1

O60500

This Nephrin monoclonal antibody is generated from mouse immunized with Nephrin recombinant protein.

WB~~1:1000

135kDa

IgM,K

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Specifically expressed in podocytes of kidney glomeruli

Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.

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