BD-PB3796

LIMK1 (9A11) Mouse Monoclonal Antibody (C-term)

LIM domain kinase 1, LIMK-1, LIMK1, LIMK

常规抗体

WB

Human, Mouse

NP_001191355.1;NP_002305.1

P53667

This LIMK1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 479-508 amino acids from the C-terminal region of human LIMK1.

WB~~1:1000

73kDa

IgM,Κ

Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.

Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P53668} Note=Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. {ECO:0000250|UniProtKB:P53668}

现货