BD-PB3773

MET/HGFR (7H5) Mouse Monoclonal Antibody

Hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met, MET

常规抗体

WB

Human

NP_000236.2;NP_001120972.1

P08581

This monoclonal antibody is generated from mice immunized with purified recombinant protein encoding the catalytic domain of human Met.

WB~~1:1000

156kDa

Mouse IgG1

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977).

Membrane; Single-pass type I membrane protein.

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