产品名称
DLDH Rabbit Polyclonal Antibody
别名
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)
蛋白名称
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1738
Human Swissprot No.
P09622
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P09622/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13382
Mouse Swissprot No.
O08749
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O08749/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=298942
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P6R2/entry
特异性
This antibody detects endogenous levels of DLDH at Human, Mouse,Rat
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion matrix . Nucleus . Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle, acrosome . Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. .
功能
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) . The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion . A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A . In monomeric form may have additional moonlighting function as serine protease . Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
