产品名称
PRD16 Rabbit Polyclonal Antibody
别名
PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)
基因名称
PRDM16 KIAA1675 MEL1 PFM13
蛋白名称
PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63976
Human Swissprot No.
Q9HAZ2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HAZ2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70673
Mouse Swissprot No.
A2A935
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2A935/entry
特异性
This antibody detects endogenous levels of PRD16 at Human, Mouse
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in uterus and kidney. Expressed in both cardiomyocytes and interstitial cells.
细胞定位
Nucleus . Cytoplasm .
功能
Binds DNA and functions as a transcriptional regulator . Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (By similarity). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (By similarity). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (By similarity). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (By similarity). Functions as a repressor of TGF-beta signaling . ; [Isoform 4]: Binds DNA and functions as a transcriptional regulator . Functions as a repressor of TGF-beta signaling . May regulate granulocyte differentiation .
