产品名称
WWP1 Rabbit Polyclonal Antibody
别名
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (Atrophin-1-interacting protein 5) (AIP5) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
蛋白名称
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (Atrophin-1-interacting protein 5) (AIP5) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11059
Human Swissprot No.
Q9H0M0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H0M0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107568
Mouse Swissprot No.
Q8BZZ3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BZZ3/entry
特异性
This antibody detects endogenous levels of WWP1 at Human, Mouse
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1.
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus .
功能
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
