BD-PT8115

YTDC1 Rabbit Polyclonal Antibody

YTH domain-containing protein 1 (Putative splicing factor YT521)

常规抗体

YTHDC1 KIAA1966 YT521

YTH domain-containing protein 1 (Putative splicing factor YT521)

WB

Human,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

91746

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91746

Q96MU7

https://www.uniprot.org/uniprotkb/Q96MU7/entry

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=0

170956

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170956

Q9QY02

https://www.uniprot.org/uniprotkb/Q9QY02/entry

This antibody detects endogenous levels of YTDC1 at Human,Rat

WB 1:500-2000 IHC 1:50-200

80kD

-15°C to -25°C/1 year(Do not lower than -25°C)

Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies. .

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate alternative splice site selection . Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules . Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist . Also recognizes and binds m6A-containing single-stranded DNA . Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).

现货