产品名称
CUL9 Rabbit Polyclonal Antibody
别名
Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
基因名称
CUL9 H7AP1 KIAA0708 PARC
蛋白名称
Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23113
Human Swissprot No.
Q8IWT3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IWT3/entry
Mouse Swissprot No.
Q80TT8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80TT8/entry
特异性
This antibody detects endogenous levels of CUL9 at Human, Mouse
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.
功能
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 . Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function .
