产品名称
MCM10 Rabbit Polyclonal Antibody
别名
Protein MCM10 homolog (HsMCM10)
蛋白名称
Protein MCM10 homolog (HsMCM10)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55388
Human Swissprot No.
Q7L590
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7L590/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70024
Mouse Swissprot No.
Q0VBD2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q0VBD2/entry
特异性
This antibody detects endogenous levels of MCM10 at Human, Mouse
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
功能
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 .
