产品名称
SYG Rabbit Polyclonal Antibody
别名
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)
蛋白名称
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2617
Human Swissprot No.
P41250
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P41250/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=353172
Mouse Swissprot No.
Q9CZD3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CZD3/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5I0G4/entry
特异性
This antibody detects endogenous levels of SYG at Human, Mouse,Rat
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed, including in brain and spinal cord. ; [Isoform 2]: Expressed in brain, spinal cord, muscle, heart and spleen. ; [Isoform 1]: Expressed in brain, spinal cord, muscle, heart, spleen and liver.
细胞定位
Cytoplasm . Cell projection, axon . Secreted . Secreted, extracellular exosome . In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524). Secreted by motor neuron, possibly through the exosome pathway (By similarity). .; [Isoform 1]: Mitochondrion . Cytoplasm .; [Isoform 2]: Cytoplasm . Cell projection, axon .
功能
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) . Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis .
