产品名称
FGFR4 (Phospho Tyr754) Rabbit Polyclonal Antibody
别名
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
蛋白名称
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2264
Human Swissprot No.
P22455
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P22455/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14186
Mouse Swissprot No.
Q03142
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q03142/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25114
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q498D6/entry
特异性
This antibody detects endogenous levels of FGFR4 (Phospho Tyr754) Rabbit pAb at Human, Mouse,Rat
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
细胞定位
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.,PTM:Glycosylated (By similarity). Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Isoform 2 may be secreted.,subunit:Interacts with KLB.,tissue specificity:Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.,
