产品名称
STAT4 (Phospho Ser721) Rabbit Polyclonal Antibody
别名
Signal transducer and activator of transcription 4
蛋白名称
Signal transducer and activator of transcription 4
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6775
Human Swissprot No.
Q14765
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14765/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20849
Mouse Swissprot No.
P42228
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P42228/entry
特异性
This antibody detects endogenous levels of STAT4 (Phospho Ser721) Rabbit pAb at Human, Mouse
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
功能
disease:Genetic variations in STAT4 are associated with susceptibility to rheumatoid arthritis (RA) [MIM:180300]. Rheumatoid arthritis is a complex, multifactorial disorder. It is one of the most common autoimmune diseases and it is characterized by inflammation of synovial tissue and joint destruction.,disease:Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.,PTM:Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.,
