产品名称
B-Myb (Phospho Thr494/497) Rabbit Polyclonal Antibody
别名
Myb-related protein B (B-Myb) (Myb-like protein 2)
蛋白名称
Myb-related protein B (B-Myb) (Myb-like protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4605
Human Swissprot No.
P10244
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P10244/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17865
Mouse Swissprot No.
P48972
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P48972/entry
特异性
This antibody detects endogenous levels of B-Myb (Phospho Thr494/497) Rabbit pAb at Human, Mouse
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
function:Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.,PTM:Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.,similarity:Contains 3 HTH myb-type DNA-binding domains.,subunit:Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.,
