产品名称
PDE4B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5142
Human Swissprot No.
Q07343
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q07343/entry
Rat Gene Link
https://www.uniprot.org/uniprot/24626
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P14646
免疫原
Synthesized peptide derived from human PDE4B AA range: 103-153
特异性
This antibody detects endogenous levels of PDE4B at Human/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
组织表达
Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015). ; [Isoform PDE4B5]: Brain-specific isoform.
细胞定位
[Isoform PDE4B5]: Cytoplasm . Cell membrane .
功能
alternative products:Additional isoforms seem to exist,catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,function:May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in brain, heart, lung and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
