产品名称
Cyclin E1 (Phospho Ser399) Rabbit Polyclonal Antibody
别名
G1/S-specific cyclin-E1
蛋白名称
G1/S-specific cyclin-E1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=898
Human Swissprot No.
P24864
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P24864/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12447
Mouse Swissprot No.
Q61457
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61457/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P39949/entry
特异性
This antibody detects endogenous levels of Cyclin E1 (Phospho Ser399) Rabbit pAb at Human, Mouse,Rat
稀释度
WB 1:500-2000 IHC 1:50-200
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
功能
function:Essential for the control of the cell cycle at the G1/S (start) transition.,PTM:Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cyclin family. Cyclin E subfamily.,subunit:Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.,tissue specificity:Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.,
