产品名称
THBG Rabbit Polyclonal Antibody
蛋白名称
Thyroxine-binding globulin (Serpin A7) (T4-binding globulin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P05543
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P05543/entry
Mouse Swissprot No.
P61939
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P61939
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P35577
免疫原
Synthesized peptide derived from part region of human protein
特异性
THBG Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012],
组织表达
Expressed by the liver and secreted in plasma.
功能
disease:Defects in SERPINA7 are a cause of TBG deficiency [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.,function:Major thyroid hormone transport protein in serum.,polymorphism:Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid. TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile.,similarity:Belongs to the serpin family.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
