产品名称
GABA A Receptor beta 3/GABRB3 Rabbit Polyclonal Antibody
蛋白名称
Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2562
Human Swissprot No.
P28472
Human Swissprot Link
https://www.uniprot.org/uniprot/P28472
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14402
Mouse Swissprot No.
P63080
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P63080/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24922
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P63079/entry
特异性
This antibody detects endogenous levels of GABA A Receptor beta 3/GABRB3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
功能
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity . The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine . Plays an important role in somatosensation and in the production of antinociception (By similarity).
