产品名称
INPP4B Rabbit Polyclonal Antibody
蛋白名称
Type II inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8821
Human Swissprot No.
O15327
Human Swissprot Link
https://www.uniprot.org/uniprot/O15327
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=234515
Mouse Swissprot No.
Q6P1Y8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P1Y8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116699
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QWG5/entry
特异性
This antibody detects endogenous levels of INPP4B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with highest levels occurring in the skeletal muscle and heart.
功能
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate . Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles . The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival .
