产品名称
NAPE-PLD Rabbit Polyclonal Antibody
蛋白名称
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=222236
Human Swissprot No.
Q6IQ20
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6IQ20
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=242864
Mouse Swissprot No.
Q8BH82
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BH82/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=296757
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q769K2/entry
特异性
This antibody detects endogenous levels of NAPE-PLD at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highest expression in brain, kidney and testis (at protein level). Expressed in adipose tissue (at protein level).
细胞定位
Golgi apparatus membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein . Nucleus envelope . Nucleus, nucleoplasm . Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids. .
功能
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid . Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity).
